The Chang lab is in the Department of Systems & Computational Biology at Albert Einstein College of Medicine. Our laboratory integrates computational modeling with biochemical and multi-omics experimentation to broadly investigate the impacts of oxidative stress (e.g., as induced by cancer therapies, radiation, toxic environmental exposures, degenerative diseases and aging) on molecules and cells. Our long-term vision is to advance understanding of mechanisms underlying both sensitivity and resistance to such stresses and harness our understanding to engineer controlled robustness of proteins and cells for technological and therapeutic applications. We work primarily in bacterial and human systems and with an emphasis on how stress relates to health and disease.